The nature of an abbreviation will indicate how to space, punctuate, write as plural forms and whether to spell out the first appearance. There are many types: the acronym, "terms based on the initial letters of their various elements and read as a single word" {NATO, AIDS}; the initialism, "terms read as a series of letters {BBC, ATM}; the contraction: "includes the first and last letters of the full word" {Mr., amt.}; symbols {$, &} and lower-case shortened forms,{Latin terminology such as ibid., and others like vol., prof.}.
Use abbreviations wisely; if strong whole words can be used, by all means do so but recognize that abbreviations give the lay-reader a handle on specialized material and provide more concise reading for the specialist.
For much more information, in addition to Chicago, consult The Copyeditor's Handbook. Despite Chicago's seemingly exhaustive list, the editors contend that "the abbreviations listed are unavoidably incomplete" and refer readers to the Merriam-Webster's Collegiate Dictionary, Abbreviations Dictionary, and the Acronyms, Initialisms and Abbreviations Dictionary.
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